Antiadhesion Effect of Materials Based on Carboxymethylchitosan and Carboxymethylcellulose

In this work, a model of adhesion formation in mice was optimized. It was shown that there were no significant differences in the level of adhesion between mouse strains (CD1, CBA, BALB/c, C57BL/6) and that the adhesion formed within 24 h after surgery and persisted for a long time. A comparative analysis of the effectiveness of materials based on carboxymethylchitosan (CMCh) and carboxymethylcellulose (CMC) in an optimized model of adhesion formation in mice was performed. It was revealed that the maximum antiadhesion efficiency was possessed by preparations of medical CMCh (mCMCh, 85%) and CMC modified by polyethylene glycol diglycidyl ether (mCMC, 87%).