Electrochemical Behavior and Voltammetric Determination of Chloramphenicol and Doxycycline Using a Glassy Carbon Electrode Modified with Single-walled Carbon Nanohorns

We report a method for the direct and quantitative determination of chloramphenicol (CAP) and doxycycline (DOX) using a glassy carbon electrode (GCE) modified with carboxylic-group-functionalized single-walled carbon nanohorns. The modified electrode exhibits high electrocatalytic activity towards the reduction of CAP and the oxidation of DOX. It shows a linear response to CAP between 0.1 mu M and 100 mu M and to DOX between 0.5 mu M and 100 mu M. The detection limits for CAP and DOX are 0.1 mu M and 0.5 mu M, respectively. The modified GCE displays good sensitivity, making it suitable for the determination of CAP and DOX in real samples.