Perioperative Effects of Hydromorphone in Gynecological Laparoscopic Surgery under General Anesthesia

Background and Objective: The laparoscopic technique has been widely used in clinical gynaecology because of its advantages on smaller wounds, low perioperative stress responses and fewer postoperative complications. It is necessary to actively examine a drug with accurate effect and high safety to reduce organ damages and promote smooth operation. This study aimed to explore the perioperative effects of hydromorphone on oxidative stress, renal and immune functions and inflammatory factors in gynaecological laparoscopic surgery under general anaesthesia. Materials and Methods: Sixty patients who underwent gynaecological laparoscopic surgery under general anaesthesia were selected and divided into 2 groups by random number table method, including a control group (n = 30, treated with the same amount of normal saline) and an observation group (n = 30, pretreated with hydromorphone). Results: The observation group had shorter anaesthesia onset time, block time and postoperative recovery time and lower anaesthesia dosage than the control group (p<0.05). The observation group had lower serum O-2(-), H2O2, OH, MDA content, BUN, UA, Cr content and TNF-alpha, IL-6 and S-100 beta contents at T-1 and T-2 but had higher GSH-Px and SOD content and serum Terg, TGF-beta 1, IL-10 levels and serum CD3+ and CD4+ levels at T-1 and T-2 than the control group (p<0.05). Conclusion: Pretreatment with hydromorphone for patients undergoing gynaecological laparoscopic surgery under general anaesthesia can relieve cellular immune suppression induced by surgical stress, improve oxidative stress responses and renal function, reduce the expression of inflammatory factors and relieve the pain degree of patients.