Longitudinal Changes in Anger, Anxiety, and Fatigue Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease
JOURNAL OF ALZHEIMERS DISEASE(2022)
摘要
Alzheimer's disease (AD) studies in cognitively normal (CN) older adults age >= 65 suggest depression is associated with molecular biomarkers (imaging and cerebrospinal fluid [CSF]). This study used linear mixed models (covariance pattern model) to assess whether baseline CSF biomarkers (A beta(42)/A beta(40), t-Tau/A beta(42) , p-Tau/A beta(42)) predicted changes in non-depressed mood states in CN older adults (N= 248), with an average of three follow-up years. Participants with higher levels of CSF biomarkers developed more anger, anxiety, and fatigue over time compared to those with more normal levels. Non-depressed mood states in preclinical AD may be a prodrome for neuropsychiatric symptoms in symptomatic AD.
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关键词
Alzheimer's disease, anger, anxiety, biomarkers, cerebrospinal fluid, older adults
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