Synthesis, characterization, and biological activity of Co(II) and Zn(II) complexes of imidazoles-based azo-functionalized Schiff bases

Ahmed R. E. Mahdy,Ola A. Abu Ali,Waleed M. Serag,Eman Fayad,Reda F. M. Elshaarawy,Emad M. Gad

Journal of Molecular Structure（2022）

引用 8|浏览7

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摘要

•New imidazoles-based azo-functionalized Schiff bases (HL1‒HL3) were successfully prepared.•The Co(II)/Zn(II) complexes of HL1‒HL3 were successfully synthesized.•New compounds were structurally and thermally characterized using various techniques.•New compounds can greatly increase the apoptosis of MCF-7 cells.•CoL3 was the most potent anticancer agent and exhibited high DNA Topo-II inhibitory activity.

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关键词

Azo-functionalized Schiff bases,Imidazoles,Co(II)/Zn(II) complexes,Flow-cytometry,Cytotoxicity

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