Systems biology analysis of pyrethroid biodegradation in bacteria and its effect on the cellular environment of pests and humans

Pyrethroid insecticides are widely used to manage crop and household pests. The extensive use of pyrethroids leads to pesticide resistance in insects and negatively affects human health. Microbial degradation of pyrethroids is an emerging method to minimize their off-target toxic effects on the environment. The main aim of this research work to compare the biomagnification of pyrethroids in different living systems in environment. This study performed a detailed analysis of pyrethroid biodegradation and toxicity using an in silico approach. Pyrethroid biodegradation was studied using a systems biology-based approach that correlated human, insect and microbial systems to achieve a comprehensive view of total environmental pyrethroid biomagnification and bioremediation. The topology of the pyrethroid model was determined using the hub nodes in cytoscape that improved the understanding of pyrethroid biodegradation and environmental losses. The results of the simulated model were used for the real-time analysis of metabolites, genes, RNA and enzymes in bacteria, insect and human cells. The model predicted the pyrethroid biochemistry and physiology in three living systems. The findings of this study elucidated the systems biology-based analysis of the effects of pyrethroids on bacterial, insect and human systems.