Lasiosiphon glaucus a potent ethnobotanical medicinal plant against breast cancer targeting multiple pathways: an invitro study

Complex synergistic interplay of the composite mixture of compounds present in plants may be the reason of their beneficial effects. In this perspective an important yet not well studied ethnomedicinal plant Lasiosiphon glaucus was subjected to invitro anticancer analysis. The flowcytometry study revealed that the plant has cytotoxic effect against breast cancer cells (MCF-7) acting upon multiple pathways, inhibiting cell proliferation (Downregulation of Bcl2 and Akt) and inducing apoptosis (Mitochondrial membrane depolarisation, Upregulation of p53, caspase 8, caspases 3 and DNA fragmentation). It is interesting that the plant activated both intrinsic and extrinsic pathways while inhibiting cancer cell proliferation. The study, a first report, highlights the use of L. glaucus in ethnomedicine for treating cancer.