PREDICTORS OF CONTRAST-INDUCED NEPHROPATHY AND THE APPLICABILITY OF THE MEHRAN RISK SCORE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

Abstract Background and Aims Contrast-induced nephropathy (CIN) after coronary angiography (CAG) is associated with poor outcomes. The purpose of our study was to identify predictors of CIN in patients undergoing CAG and to evaluate the applicability of the Mehran Risk Score (MRS) in the prediction of CIN in our population. Method We prospectively enrolled 158 patients who underwent coronary angiography with or without percutaneous coronary intervention from December 2017 to February 2018 at a cardiology department . CIN was defined as an increase in serum creatinine level >25% or 0.5 mg/dL after 48 hours postcardiac catheterization. The patients who developed CIN were then analysed for the presence of specific risk factors. The patients were categorized into the 4 risk groups based on the MRS. Results The incidence of CIN was 9,5%. On multivariate analysis, the presence of anemia (p = 0.043), toxic contrast dose (as defined by ratio volume of contrast media to estimated glomerular filtration rate (V/eGFR) > 2) (p = 0.02) and chronic renal failure (p = 0.026) were independently found to confer a significant risk of CIN. In patients belonging to the high Mehran risk group (MRS10- 15) the risk of CIN was 3,7 fold (OR: 3.7, 95% CI: 0,88–15,6, p = 0.036) higher when compared to intermediate and low risk patients (MRS <10). Conclusion Mehran risk score is as a good score for predicting CIN in patients who underwent coronary angiography. According to this, we support its use in order to identify the ones at risk, and to optimize CIN prophylactic therapy prior to and after catheterization.