Exploration of benzimidazoles as potential microtubule modulators: An insight in the synthetic and therapeutic evolution

The dynamic microtubules are one of the most fruitful targets for cancer chemotherapy. The outcomes of various studies depict that the benzimidazole framework is a fundamental moiety in various synthetic analogues, signifying a myriad scope of therapeutic activities. These scaffolds have also established their place as prospective tubulin polymerisation inhibitors in the medicinal chemistry arena. In this regard, the current review demonstrates a comprehensive report on the design and synthetic strategies engaged in developing various benzimidazole-bearing heterocyclic molecules as promising cytotoxic agents acting as tubulin polymerisation modulators. The detailed assessment of antiproliferative activities with reference drugs allows a proficient assessment of the structure-activity relationships (SARs) of the diversely synthesised benzimidazole hybrids.