Preparation and Properties Characterization of Polysiloxane Skin Tissue Adhesive

Skin is inevitably injured as the outermost organ of human body in daily life. Suture is the main methods to deal with the open skin wounds. However, even if suture can effectively close the open wounds, it may cause some defects such as secondary damage and scars. It is ideal to develop the tissue adhesive with good performance to replace the suture. Based on the analysis of properties requirements of skin tissue adhesive, a polysiloxane skin tissue adhesive was designed and synthesized which is consisted of prepolymer poly(dimethyl siloxane)(n)-co-poly(propoxybenzaldehyde methyl siloxane)(m)(PDMSn-PBAMS(m)), crosslinker poly(hydromethyl siloxame)PHMS and Karstedts catalyst. Among them, the side groups of prepolymer with functional modification can covalently interact with skin, prepolymer and PHMS can occur rapid in situ curing reaction to achieve adhesion on skin. The results indicate that polysiloxane tissue adhesive has compatible mechanical properties with skin through adjusting the degree of polymerization(DP) of prepolymer, modified proportion of functional group and content of PHMS. The adhesion tests indicate that the polysiloxane has good adhesive property for hogskin and the maximum shear adhesive strength is 77.6 kPa. In addition, prepolymer and PHMS complete in situ curing process in about 100 s at room temperature. Polysiloxane adhesvie can meet the property requirements as a good skin tissue adhesive and has a good application prospect in regenerative medicine.