The relationship between the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio and tumor characteristics in patients with breast cancer Inflammatory markers in breast cancer

Aim: Many studies nowadays increasingly enlighten the nature of relationship between cancer and inflammation. NLR and PLR are proinflammatory indicators that are related to many clinicopathological characteristics of many types of cancer. in this study, we aimed to find out the relationship between NLR and PLR values and tumor characteristics in patients with breast cancer that are operated with help of basic and inexpensive peripheral blood test results. Material and Methods: A database of 94 female patients who were operated in the Department of Surgical Oncology of the Medical School of Ankara University was studied. All blood sample tests, pathology reports, immunohistochemical staining results of the patients were retrospectively scanned. Patient demographics and pathological properties of tumor obtained from the database. The NLR and PLR values were taken from the peripheral blood cell count Data were presented as average valuetstandart deviation(SD), and maximum-minimum values. Later data were analyzed. Results: NLR values were significantly different accordingly to T stage of tumor (=11.452; p=0.022). On the other hand, the PLR value did not show a significant differentiation according to tumor size (=5.865; p=0.209). It has been seen that this differentiation is between T1 and T2; T1 and T3 statistically. (U= 251.000 p=0.003; U=54.000, p=0.021). Discussion: The NLR value is significantly related to the tumor size. But further research is needed to see the clinical reflection and added value to the clinical practice of these results.