Towards the total synthesis of metacridamides A and B
TETRAHEDRON LETTERS(2022)
摘要
Two different strategies have been considered to achieve the total synthesis of metacridamides A and B. The first approach based on Horner-Wittig olefination reaction was unsuccessful. The second approach, involving desymmetrization, a highly diastereoselective aldolization, Wittig olefination, amide formation and finally tethering formation, furnished an advanced intermediate 39 with all stereocenters present in metacridamides A and B. (C) 2022 Published by Elsevier Ltd.
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关键词
Natural products, Cytotoxic, Desymmetrization, Wittig olefination, Aldolization, Tethering formation
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