New strategy for selective voltammetric determination of norepinephrine using modified electrode by using benzoyl ferrocene and manganese ferrite nanoparticles

Norepinephrine (NE) is one of the most important catecholamine neurotransmitters in the central nervous system and play an important role in health and diseases. Therefore, the determination of NE in biological samples is important for human health control purposes. In the present work, a new sensor has been constructed using a carbon paste electrode (CPE) modified by using benzoyl ferrocene and manganese ferrite nanoparticles (MF NPs) for norepinephrine determination. The hydrothermal method was used for synthesis of MF NPs. The synthesized NPs have been characterized by XRD pattern, scanning electron microscope (SEM), FT-IR, and EDX measurements. The obtained results illustrate that, the synthesized MF NPs have the spherical morphology with a mean diameter of 27.6 nm. The obtained data showed that the oxidation of NE at the surface of the modified CPE compared to bare CPE occurs at lower potentials and with higher current intensities. The oxidation peak current increased linearly with concentration over the two range of 0.03–10.0 µM and 10.0–500.0 µM with the detection limit of 20.0 nM. The reproducibility and stability of sensor were excellent and used successfully to detect of NE in blood serum and urine samples and high recoveries were obtained.