Lupanes and friedelanes, the first chemical constituents of the aerial parts of Maytenus erythroxylon Reissek

The first phytochemical study of the aerial parts of Maytenus erythroxylon Reissek resulted in the isolation of five triterpenes, two with a lupane skeleton: 29-norlupan-3,20-dione (1) and 30-hydroxy-20 (29)-lupen-3-one (2) and three with friedelane skeleton: 3,4-secofriedelan-3-oic acid (3), 3-oxo-30-hydroxyfriedelane (4) and 3 beta-Hydroxyfriedelane (5), where the compound (1) is reported for the first time in the Maytenus genus. The structures were identified through the analysis of uni and two-dimensional NMR spectral data. The isolated phases and compounds were subjected to in silico and in vitro techniques to evaluate the microbiological potential against microorganisms that cause intestinal disorders, showing that only the compound (3) was able to inhibit Candida spp. strains.