New lignans and a phenylpropanoid from Triadica rotundifolia and their antineuroinflammatory and antioxidant activities

Three new compounds (1-3), including a phenylpropanoid (1), a bistetrahydrofuran lignin (2), and a lignan dimer (3), and seven known lignans (4-10), were isolated from an EtOH extract of the aerial parts of Triadica rotundifolia. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. New compounds 1-3 were evaluated for their antineuroinflammatory and antioxidant activities. Research on the antineuroinflammatory activity suggested that compounds 2 and 3 had significant inhibitory effects on NO production in LPS-induced BV-2 cells, with the IC50 values of 15.7 and 5.8 mu M, respectively. Meanwhile, compounds 2 and 3 exhibited better DPPH free radical scavenging activities with EC50 values of 2.0 and 4.3 mu M, respectively, than the positive control vitamin C (EC50 = 14.3 mu M).