Recent advances in the generation and functionalization of C(alkenyl)-Pd species for synthesis of polysubstituted alkenes

The synthesis of polysubstituted alkenes represents a formidable challenge in organic synthesis. Over the years, many advances have been made for this purpose, yet challenges persist in terms of selectivity, scope, and efficiency. Palladium-catalyzed methods for alkene synthesis are attractive within this field given that cross-coupling is particularly impactful in the construction of organic molecules due to palladium's ability to facilitate modular carbon-carbon and carbon-heteroatom bond formation. To employ palladium catalysis for alkene synthesis, the generation and subsequent functionalization of C(alkenyl)-Pd intermediates are key steps. In this review, we highlight research advances since 2000 in the area of polysubstituted alkene syntheses involving C(alkenyl)-Pd species. (c) 2021 Elsevier Ltd. All rights reserved.