Overall survival analysis of > 65-year-old patients with breast cancer based on their molecular, clinicopathological and laboratory factors
ARCHIVES OF MEDICAL SCIENCE(2022)
摘要
Introduction: The objective of the present study was to characterize > 65- year-old patients with breast cancer according to clinicopathological, molecular and laboratory factors. Methods: A total of 723 breast cancer patients, who had been diagnosed and treated during 2005-2019, were retrospectively reviewed. Patients > 65 years of age (92 patients) were compared with < 50-year-old women (306 patients). We analyzed 398 women from 723 patients. Results: Overall survival analysis was conducted for both groups, separately and combined. Patients with BC aged > 65 years were characterized by G1-2, higher lymphocyte values, lower platelet (PLT) counts and lower NLR or PLR values than patients < 50 years of age. Conclusions: Age > 65 years is a negative prognostic factor independent of other factors.
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关键词
breast cancer, neutrophil, to-lymphocyte ratio, platelet-to-lymphocyte ratio, platelet, BRCA, checkpoint kinase 2, nucleotide binding oligomerization domain containing 2 mutation
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