Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation.

Xuezhen Zeng,Guanrui Liao,Shumin Li,Haining Liu,Xiao Zhao,Shuang Li,Kai Lei,Shenghua Zhu,Zhihang Chen,Yi Zhao,Xuxin Ren,Tianhong Su,Alfred Sze-Lok Cheng,Sui Peng,Shuibin Lin,Ji Wang,Shuling Chen,Ming Kuang

Hepatology (Baltimore, Md.)（2023）

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摘要

Our study sheds light on the pivotal role of METTL1 in modulating an immunosuppressive microenvironment and demonstrated that interrupting METTL1-TGF-β2-PMN-MDSC axis could be a therapeutic strategy to restore antitumor immunity and prevent HCC recurrence after RFA treatment, meriting further clinical studies.

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