The microenvironment of silk/gelatin nanofibrous scaffold improves proliferation and differentiation of Wharton’s jelly-derived mesenchymal cells into islet-like cells

Anis Taherpour,Zahra Hosseini-Khah,Mehryar Zargari,Seyed Ehsan Enderami

Gene（2022）

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摘要

•Silk/gelatin scaffold has been effective microenvironment in differentiation WJ-MSCs to IPCs.•Expression of pancreatic genes in 3D culture, increased significantly compared to the 2D culture.•Expression of insulin protein in 3D culture, increased significantly compared to the 2D culture.•The secretion of insulin and C-peptide in the 3D cutture was significantly higher than in 2D culture.

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关键词

Insulin-producing cells,Umbilical cord derived-stem cells,Wharton’s jelly,Silk/gelatin scaffold,Differentiation

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