In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics

Akio Aono,Yoshiro Murase,Kinuyo Chikamatsu,Yuriko Igarashi,Yoshiko Shimomura,Makiko Hosoya,Asami Osugi,Yuta Morishige,Akiko Takaki,Hiroyuki Yamada,Satoshi Mitarai

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE（2022）

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摘要

The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD. (c) 2022 Elsevier Inc. All rights reserved.

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关键词

Tedizolid, Linezolid, Multidrug resistance, Mycobacterium tuberculosis, Minimum inhibitory concentration, Bone marrow suppression

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