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Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.

Martin Schepelmann,Marianna Ranieri,Irene Lopez-Fernandez,Thomas S Webberley,Sarah C Brennan,Polina L Yarova,Joao Graca,Umar-Khetaab Hanif,Christian Müller,Teresa Manhardt,Martina Salzmann, Helen Quasnichka,Sally A Price,Donald T Ward,Thierry Gilbert,Vladimir V Matchkov,Robert A Fenton,Amanda Herberger,Jenna Hwong,Christian Santa Maria,Chia-Ling Tu,Enikö Kallay,Giovanna Valenti,Wenhan Chang,Daniela Riccardi

Journal of the American Society of Nephrology : JASN（2022）

Cited 6|Views17
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Abstract
These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.
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Key words
calcium-sensing receptor,hypercalcemia,mineral metabolism,transgenic mouse,vascular calcification,vascular smooth muscle
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