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UV radiation damage of human gamma D crystallin: role of tryptophans

Lina A. Rivillas-Acevedo, Yissell Borges-Rodriguez

Biophysical Journal（2022）

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Abstract
Cataract is one of the main causes of blindness worldwide and is due to aggregation of eye lens proteins. Age, UV radiation, oxidation, metal ions, deamidation, and truncations are factor risks that cause protein damage and induce aggregation. Human γD (HgD) crystallin is one of the most abundant crystallins in the lens nucleus and its non-amyloid aggregation is
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gamma,radiation damage,tryptophans,uv
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