Optimization of novel lead compounds for treatment of long QT syndrome

The purpose of this study is to optimize the therapeutic potential of IKs (KCNQ1/KCNE1) channel activating Poly Unsaturated Fatty Acids (PUFAs) by using computational and experimental methods to increase their potency and specificity. We hypothesize that the computational method, Site Identification by Ligand Competitive Saturation (SILCS), will further elucidate the chemical environment and potential compound interactions in the known PUFA binding sites on the IKs channel allowing us to edit our PUFA structures to enhance their binding affinities and thus IKs activation.