Comparative Characteristics of Glutamate Dehydrogenase Functioning in Cyprinus carpio and Unio pictorum under the Impact of Elevated Metal Ions Concentrations

The role of the glutamate dehydrogenase system in the tissues of fish and bivalve mollusks in maintaining the homeostasis of protein metabolism intermediate products, changing its direction and also in the ammonia detoxification processes under the impact of elevated metal ions concentrations has been studied. It was found that the direction of the glutamate dehydrogenase reaction under the impact of heavy metal ions as a rule shifts towards the glutamate synthesis, which is a reason of α-ketoglutarate removal from tricarboxylic acid cycle and disruption of the energy metabolism in the tissues.