Cascade-Reaction-Triggered Engineering Nanocatalytic Theranostics Reconstructing Tumor Microenvironment Through Synergistic Oxidative Damage and Aerobic Glycolysis Inhibition Against Colon Cancer

•A pH/ROS responsive nanocatalytic theranostics realized on-demand cargo releasing.•The nano-platform reconstructed abnormal energy metabolism in tumor microenvironment.•The nanocatalyst triggered cascade processes in response to tumor microenvironment.•The integration of GOx, Fe3O4 and RA-V achieved highly orchestrated cooperation.•The nano-platform realized remarkable anticancer activity in vitro and in vivo.