Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer.

Hidetaka Suzuki,Shuichi Mitsunaga,Masafumi Ikeda,Takao Aoyama,Kazumi Yoshizawa,Masayuki Yamaguchi,Masami Suzuki,Minoru Narita, Toshikatsu Kawasaki,Atsushi Ochiai

Cancer medicine（2022）

引用 3|浏览5

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摘要

Biological activity of IL-6/gp130 axis promoted N-inv in murine model and was upregulated in PDAC patients with severe N-inv. This study is the first evidence that the IL-6/gp130 axis offers a potential therapeutic target in PDAC with N-inv.

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关键词

mouse models,pancreatic cancer,pancreatic ductal adenocarcinoma,translational research

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