Putting introns on retainer
NATURE CHEMICAL BIOLOGY（2022）
摘要
Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.
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关键词
Cancer therapy,Chemical genetics,RNA splicing,Small molecules,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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