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Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model

Naif O Al-Harbi,Sheikh F Ahmad,Mohammed Almutairi,Ahmed Z Alanazi,Khalid E Ibrahim,Saleh A Alqarni,Faleh Alqahtani,Khalid Alhazzani,Metab Alharbi,Fawaz Alasmari,Ahmed Nadeem

Cellular Immunology（2022）

Cited 11|Views2
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Abstract
•There is increased Lck expression in CD4+ T cells during psoriatic inflammation.•Lck is linked with increase in Th1/Th17 cells during psoriatic inflammation.•Blockade of Lck causes decrease in Th1/Th17 cells during psoriatic inflammation.•Blockade of Lck improves psoriasis-associated clinical/biochemical parameters.
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Key words
Psoriasis,Lymphocyte-specific protein kinase,TNF-α,IFN-γ,Imiquimod
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