A novel treatment strategy of HER2-targeted therapy in combination with Everolimus for HR+/HER2- advanced breast cancer patients with HER2 mutations

Jing Ma,Xuelu Li,Qianran Zhang,Ning Li,Siwen Sun,Shanshan Zhao,Zuowei Zhao,Man Li

Translational Oncology（2022）

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摘要

•Trastuzumab combined with Everolimus is an effective treatment for ER+/HER2-HER2-mutant breast cancer patients.•HER2 mutant breast cancer cells are highly sensitive to the combination of HER2-targeted therapies and Everolimus.•Lapatinib combined with Everolimus inhibits HER2 downstream signaling.

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关键词

HER2 mutation,Breast cancer,HER2-targeted therapy,Everolimus,Treatment

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