Impact of add-back FSH on human and mouse prostate following gonadotropin ablation by GnRH antagonist treatment.

Eleftherios E Deiktakis,Eleftheria Ieronymaki,Peter Zarén,Agnes Hagsund,Elin Wirestrand,Johan Malm,Christos Tsatsanis,Ilpo T Huhtaniemi,Aleksander Giwercman,Yvonne Lundberg Giwercman

Endocrine connections（2022）

引用 3|浏览16

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摘要

These data provide novel evidence for the direct effects of FSH on prostate size and gene expression in chemically castrated mice. However, in chemically castrated men, FSH had no effect on PSA production. Whether FSH effects on the prostate in humans also require suppression of the residual adrenal-derived androgens and/or a longer period of rFSH stimulation, remains to be explored.

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关键词

PSA,castration,degarelix,follicle-stimulating hormone,prostate

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