Spectral crosstalk in photoacoustic computed tomography
Photoacoustics(2022)
摘要
Multispectral photoacoustic (PA) imaging faces two major challenges: the spectral coloring effect, which has been studied extensively as an optical inversion problem, and the spectral crosstalk, which is basically a result of non-ideal acoustic inversion. So far, there is no systematic work to analyze the spectral crosstalk because acoustic inversion and spectroscopic measurement are always treated as decoupled. In this work, we theorize and demonstrate through a series of simulations and experiments how imperfect acoustic inversion induces inaccurate PA spectrum measurement. We provide detailed analysis to elucidate how different factors, including limited bandwidth, limited view, light attenuation, out-of-plane signal, and image reconstruction schemes, conspire to render the measured PA spectrum inaccurate. We found that the model-based reconstruction outperforms universal back-projection in suppressing the spectral crosstalk in some cases.
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关键词
Multispectral photoacoustic imaging,Quantitative photoacoustic imaging,Photoacoustic image reconstruction,Photoacoustic computed tomography,Optoacoustic computed tomography,Spectral crosstalk
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