Investigating the Activity of Indole-2-on Derivative Src Kinase Inhibitors Against Chronic Myeloid Leukemia Cells.

Aysegul Cort-Donmez,Sureyya Olgen,Ersin Guner,Gulsum Akgun-Cagliyan,Ferhat Hanikoglu,Melek Tunc-Ata,Emine Kilic-Toprak

Anti-cancer agents in medicinal chemistry（2023）

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摘要

Among indole-2-on derivatives, previously identified as Src kinase inhibitors, C-2 has been discovered to be a strong anticancer drug that is active against susceptible and resistant K562 cell lines and induces apoptosis.

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关键词

ABl,Indole-2-on derivatives,Src,anti-proliferative,cell viability,docking

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