Pos-240 cgas/sting decreates renal fibrosis and inflammatory response induced by hypertension by regulating glutathine metabolisn
Kidney International Reports(2022)
摘要
Hypertension, an important risk factor for cardiovascular and end-stage renal disease, often aggravates renal injury and compromises kidney function. Renovascular hypertension (RVH) is one of the most common causes of secondary hypertension. Ischemia hypoxia and activation of Renin-angiotensin-aldosterone System (RAAS) are the main pathologic processes of this disease.Blockade of RAAS by administration of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-receptor blockers (ARBs) can dramatically remove renal function.
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关键词
cgas/sting decreates renal fibrosis,induced by hypertension,inflammatory response
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