Photoregulation of small G-protein RAS by the modification at HVR using azobenzene derivatives

Ras is one of the Small G proteins functioning as a molecular switch, is a central regulator of cellular signal transduction processes leading to transcription, cell cycle progression and differentiation by cycling between the inactive GDP-bound and the active GTP-bound states using GAP and GEF regulators. The structure and functional mechanism of Ras have been well studied and considered as a GTP driven nanomachine which control cellular function. Hyper Variable Region (HVR) is one of the functional parts of the G proteins in which modification induce multimerization and interaction with plasma membrane of Ras.