Comparing Clinical Outcomes Between Two Continuous Glucose Monitors: Similar Diabetes-Related Events, All-Cause Hospitalizations and HbA1c Reductions in Type 1 and Type 2 Diabetes
American Journal of Medicine Open(2022)
Abstract
We compared clinical outcomes after acquiring a FreeStyle Libre© Flash Continuous Glucose Monitoring System (FSL) or Dexcom (DEX) continuous glucose monitoring (CGM) device in individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D) treated with intensive insulin therapy. This retrospective analysis of the IBM® MarketScan® Research Databases and IBM® Explorys® Electronic Health Records Database assessed changes in acute diabetes-related events (ADE), all-cause hospitalizations (ACH) and glycated hemoglobin (HbA1c) in T1D and T2D populations 6 months post CGM acquisition. Analyses were conducted in two study cohorts (Cohort 1, n=7,494; Cohort 2, n=678). Participants were T1D or T2D, age ≥18 years, treated with short or rapid-acting insulin and naïve to CGM, who acquired a CGM system. Users were propensity score matched on demographics and clinical factors. Cohort 1: Post-CGM ADE-free rates at 6 months ranged from 94.8-96.7% and ACH-free rates ranged from 90.4-95.4%, with no significant differences between CGM systems. Cohort 2: Significant HbA1c reductions were associated with use of the DEX and FSL devices in the T1D (-0.35% and -0.37%, respectively) and T2D (-0.73% and -0.79%, respectively) cohorts, both p<0.001, with no significant differences in the magnitude of reduction between systems (T1D p=0.99 and T2D p=0.84). Acquisition of the FSL and DEX systems was associated with similar rates of acute diabetes-related events and all-cause hospitalizations and similar HbA1c reductions in adults with T1D and T2D.
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