Dendritic Nanostructures for Effector Cell Activation to Study Allergic Reactions to Amoxicillin

Amoxicillin (AX) is the penicillin currently regarded as the main culprit in eliciting allergic reactions. According to hapten hypothesis, AX immunogenicity can only be gained by forming covalent conjugates with proteins. Structural properties of conjugates could be nano-engineered to be appropriate for crosslinking of specific IgE (sIgE) bound to high-affinity receptor on basophils or mast cells (MCs).