Pos-404 linc00355 mediates ctnnbip1 promotor methylation and promotes er stress-induced podocyte injury in diabetic nephropathy

Podocyte injury is a crucial feature of many glomerular disease,including diabetic nephropathy (DN) which is one of the most common microvascular complications of diabetes mellitus and the main cause of death and disability in diabetic patients. Recently,a series of studies have shed lighti on the role of epigenetic changes such as histone protein modifications played in podocyte injury of glomerular disease.Endoplasmic reticulum stress (ER stress) plays an important role in podocyte injury in diabetic nephropathy.