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Alveolar Macrophage P2Y6 Receptor Signaling Regulates NFATC2 Activation to Enhance Protective Innate Immune Responses

Jun Nagai,Junrui Lin,Barbara Balestrieri,Joshua Boyce

The Journal of Allergy and Clinical Immunology（2022）

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Abstract
Alveolar macrophage P2Y6 receptor signaling prevents adaptive type 2 allergic inflammation through the enhancement of IL-12 production by alveolar macrophage during the innate phase of dust mite exposure. However, the mechanisms through which alveolar macrophage P2Y6 receptors facilitate IL-12 production and reinforce the innate immune response is still unknown.
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Key words
macrophage,immune responses,signaling
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