Synthesis and bio-activity studies of urea/thiourea derivatives of 4, 4’-diamino biphenyl methane

The title compounds urea/ thiourea derivatives of 4,4'-diamino biphenyl methane were synthesized from the reaction of 4,4'-methylenedianiline with some aryl isocyanates and aryl isothiocyanates in the presence of 1,4-dimethyl piperazine catalyst and obtained the products with 80-91% yields. The structures of all the newly synthesized urea/ thiourea derivatives were confirmed by spectral (IR, 1H, 13C NMR & MS) and analytical studies. The synthesized compounds were screened for their antibacterial activity against Bacillus substilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae; and antifungal activity against Candida albicans and Candida nonalbicans fungi. In conclusion, it is identified that some compounds have shown significant antibacterial activity. Similarly, it is identified that some compounds have shown significant antifungal activity.