Silencing of B7H4 Represses the Development of Oral Squamous Cell Carcinoma Through Promotion of M1 Macrophage Polarization

Jingwen Chi,Yicong Liu,Lixia Yang,Jianjun Yang

Journal of Oral and Maxillofacial Surgery（2022）

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摘要

B7H4 is upregulated during OSCC progression. Its downregulation may promote M1 macrophage polarization and inhibit M2 macrophage polarization via deactivating the PD-1/STAT3 pathway, thus restraining OSCC development.

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关键词

oral squamous cell carcinoma,squamous cell carcinoma,macrophage,b7h4

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