In-vivo non-contact functional and structural ophthalmic imaging using a dual-modal photoacoustic remote sensing and swept-source optical coherence tomography system

In this work, a synchronized dual-modal imaging system is used for in-vivo, non-contact ophthalmic imaging. The apparatus is comprised of both Photoacoustic Remote Sensing (PARS) and Swept-Source Optical Coherence Tomography (SS-OCT) subsystems. The PARS utilizes a multi-wavelength excitation source to target hemoglobin absorption and an 830 nm interrogation source to detect photoacoustic signals. PARS provides the measurements for computing blood oxygen saturation (sO2) mapping in the mouse and rat eyes. Meanwhile, a 1060 nm SS-OCT is employed to obtain volumetric tissue structure. To our knowledge, this is the first report of non-contact functional photoacoustic imaging in ophthalmic applications.