Implementation of HCV screening in the 1969‐1989 birth‐cohort undergoing COVID ‐19 vaccination: A pivotal study in Italy
Liver International(2022)
Abstract
Background and Aim The World Health Organization (WHO) goal of hepatitis C virus (HCV) elimination by 2030 relies on the scaling-up of both identification and linkage to care of the infected population, worldwide. In Italy, the estimated burden of HCV carriers who are unaware of their infection amounts to 200,000 persons, a projection that reinforces the need for broadening population access to effective screening programs. Methods A pivotal screening program targeting subjects born between 1969 and 1989 has been conducted in Lombardy, Northern Italy, where point-of-care (POC) testing was offered for free concomitantly to COVID-19 vaccination. Results Among 7,219 subjects born between 1969 and 1989 who underwent HCV screening through POC, 7 (0.1%) subjects tested anti-HCV positive and 5 (0.07%) had confirmed anti-HCV and HCV-RNA positivity by standard confirmation tests. Conclusions This pivotal study demonstrated the feasibility of a POC-based anti-HCV screening program in young adults undergoing COVID-19 vaccination. The prevalence of HCV infection in subjects born in the 1969-1989 cohort in Italy seems to be lower than previously estimated. Whether the extension of this program to subjects born before 1969 could lead to improved screening effectiveness should be matter of debate.
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Key words
HBV Infection
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