Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties

Some novel enantiopure 3-carboxylic isoxazolidine derivatives were synthesized by stereocontrol 1,3-dipolar cycloaddition (1,3-DC) between nitrone derived (-)-menthone with alkenes derived from phenol and benzyl alcohol. Furthermore, the synthesized molecules were optimized for their drug-likeness and pharmacokinetics parameters by using in silico methods.