Spatio-temporal optical coherence tomography provides advanced in vivo imaging of the human retina and choroid

Despite the rapid development of OCT, high-resolution in vivo imaging of human eye with penetration into deeper retinal layers and choroid is still a major challenge due to its sensitivity to coherent noise, such as speckle and crosstalk. To address that, we have developed a technique termed Spatio-Temporal Optical Coherence Tomography (STOC-T) that uses light with controlled spatial and temporal coherence to obtain high-contrasted coronal projection images of the choroid at various depths including that of choriocapillaris. It can also detect blood flow and reveal vascular networks in various chorioretinal layers that are otherwise invisible to OCT.