KS-WNK1 is Required to Translate the Response to Extreme Changes in Potassium Ingestion to NCC Activity and Expression.

No differences were observed between WT and KS-KO in groups fed with NKD before the exposure to HKD. KS-WNK1 was not expressed during NKD. In contrast, in mice fed with 0KD, our data show that activation of NCC was higher in WT that KS-KO. Then, after HKD, down-regulation of pNCC was more effective in WT than in KS-KO mice. Therefore, our data suggest that KS-WNK1 is not present and has no role when mice were fed with NKD, but is up-regulated in 0KD and therefore, required to properly respond to extreme changes in potassium diet, as those that occurs in wildlife mammals.