Lipocalin-2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high-fat diet-fed Ob/Ob mice.

Hepatology (Baltimore, Md.)（2023）

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摘要

LCN2 acts as a key mediator of HSC activation in leptin-deficient obesity via α-SMA/MMP9/STAT3 signaling, thereby exacerbating NASH.

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关键词

hepatic stellate cells,lipocalin‐2,nonalcoholic steatohepatitis,high‐fat diet–fed

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