Combining donor derived cell free DNA and gene expression profiling for non-invasive surveillance after heart transplantation.

Erik J Henricksen,Yasbanoo Moayedi,Saira Purewal, Julien Valverde Twiggs,Kian Waddell,Helen Luikart,Jiho Han,Kent Feng,Brian Wayda,Roy Lee,Yasuhiro Shudo,Shirin Jimenez,Kiran K Khush,Jeffrey J Teuteberg

Clinical transplantation（2023）

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摘要

Compared to post-transplant rejection surveillance with GEP alone, pairing dd-cfDNA and GEP testing was associated with similar survival and rejection-free survival at 1 year while requiring significantly fewer biopsies.

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关键词

biomarker,dysfunction,graft survival,heart (allograft) function,rejection

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