GRK2, a novel regulator of skeletal development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
Abstract
We show a novel role of GRK2 in skeletal development as a major regulator of PTH1R in GP chondrocytes. GRK2-icKO increases chondrocyte proliferation and reduces hypertrophy and apoptosis, leading to reduced bone deposition, matrix mineralization, and shorter bones. Altogether, this presents GRK2 as a novel therapeutic target for skeletal abnormalities.
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Key words
novel regulator
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