Comparative Studies on the Interaction of Heparins from Various Origins with Heparin Cofactor II and Antithrombin.

These results show that potency adjusted UFH's exhibit comparable inhibition of IIa in AT and HCII enriched systems. The differing BMH results observed in these two systems at gravimetric concentrations may partly be due to differences in charge density and AT-binding consensus sequences. The depolymerized enoxaparin of different origins did not reveal any significant differences in the IC-50 values. This may be due to the chemical modifications that occur during the manufacturing of these agents. Future studies may be warranted to further investigate these cofactors and their impacts on the function of various heparins.