Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle br

There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims to prepare a theranosticcancer vehicle based on porous silica nanoparticles (PSN) with controllable nanoparticlesize, supporting targeting properties, and biocompatible. The synthesis method combinedthe Sto??ber process and liquid crystal templating using a dispersant and pore expander.Triethanolamine (TEA) and Pluronic F-127 were combined as a steric stabilizer anddispersing agent, whilen-hexane was used as a pore expander. The amine functionalizationwas carried out using the 3-aminopropyl-triethoxysilane solution. Furthermore, radiolabelingof PSN using Iodine-131 and iodogen as oxidizing agents was carried out. The resultsshowed that the best achievable PSN size was 100-150 nm with a polydispersity index of0.24 using TEA-Pluronic F-127. The functionalization results did not significantly affect theradioiodination result. Radiochemical purity (RCP) values up to 95% were obtained in theradioiodination, while the labeled compounds were relatively stable with 12 mCiradioactivity, indicating the absence of radiolysis. The synthesized PSN was not toxic to normal cell samples up to a concentrationof 150 mu g/mL for PSN and 170 mu g/mL for PSN-NH2. The cellular uptake testing results of the PSN-131I in cancer cell samples showed promising uptake ability